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94154: TMAO (Trimethylamine N-oxide) Print View
TMAO (Tri N-oxide)     uM 

PRIMARY
1 Serum 1 (0.5) mL   Frozen - 21 Day(s)/Refrigerated - 7 Day(s)  
ALTERNATE
  Plasma EDTA 1 (0.5) mL   Frozen - 21 Day(s)/Refrigerated - 7 Day(s)  

Gut microbes live symbiotically within the human digestive tract and play important roles in host defense, immunity, and nutrient processing and absorption. This diverse community is unique to each person and influenced by both acute and chronic dietary exposures to various food sources. Nutrients such as phosphatidylcholine (also known as lecithin), choline, and L-carnitine are abundant in animal-derived products such as red meat, egg yolk and full-fat dairy products. When consumed, these nutrients are processed by gut bacteria resulting in the release of various metabolites including TMA (trimethylamine) into the blood. TMA is then transported to the liver where it is converted into TMAO (trimethylamine N-oxide) which has been shown to regulate various physiological processes involved in the development of atherosclerosis.

1. Collect and label sample according to standard protocols.
2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
3. Allow blood to clot 30 minutes.
4. Centrifuge at 1300 rcf for 10 minutes.

EDTA plasma may be used for TMAO only if serum is not available.

Plasma:
1. Gently invert 8-10X (DO NOT SHAKE!).
2. Centrifuge immediately at 1300 rcf for 10 min.
3. Aliquot top layer from lavender top draw tube and place PLASMA into
transport tube and dispose of draw tube. Label the transport tube as
EDTA plasma. ONLY ship plasma in transport tube.
4. Store and transport refrigerated.

Patient Preparation:
Patients should fast overnight and refrain from consuming fish or
other seafood the day before the blood draw to avoid false elevations
in TMAO.
Setup Schedule
Monday-Saturday

Reported (Analytical Time)
9-12 days

CPT Code
82542

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Refrigerated
Specimen Stability:
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen (-20 degrees Celsius): 21 days
Frozen (-70 degrees Celsius): 21 days
Methodology: Liquid Chromatography-Tandem Mass Spectrometry






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