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94154: Tmao (trimethylamine N-oxide) Print View
TMAO (Tri N-oxide)     uM 

PRIMARY
1 Serum 1 (0.5) mL   Frozen - 21 Day(s)/Refrigerated - 7 Day(s)  
ALTERNATE

Gut microbes live symbiotically within the human digestive tract and play important roles in host defense, immunity, and nutrient processing and absorption. This diverse community is unique to each person and influenced by both acute and chronic dietary exposures to various food sources. Nutrients such as phosphatidylcholine (also known as lecithin), choline, and L-carnitine are abundant in animal-derived products such as red meat, egg yolk and full-fat dairy products. When consumed, these nutrients are processed by gut bacteria resulting in the release of various metabolites including TMA (trimethylamine) into the blood. TMA is then transported to the liver where it is converted into TMAO (trimethylamine N-oxide) which has been shown to regulate various physiological processes involved in the development of atherosclerosis.

Patient Preparation:
Patients should fast overnight and refrain from consuming fish or
other seafood the day before the blood draw to avoid false elevations
in TMAO.

Instructions:
1. Collect and label sample according to standard protocols.
2. Gently invert 5X immediately after draw (DO NOT SHAKE!)
3. Allow blood to clot 30 min. at room temperature.
4. Centrifuge for 10 min.
5. Store and transport refrigerated.
Setup Schedule
Monday-Saturday

Reported (Analytical Time)
7 days

CPT Code
82542

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Refrigerated
Specimen Stability:
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen (-20 degrees Celsius): 21 days
Frozen (-70 degrees Celsius): 21 days
Methodology: Liquid Chromatography-Tandem Mass Spectrometry
Reject Criteria:
* Specimens other than serum * Improper labellling * Samples not stored properly * Samples older than stability limits ** Plasma is no longer acceptable **






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