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94206: Adalimumab Activity And Neutralizing Antibody Print View
Adalimumab Activity     ug/mL 
Adalimumab Neutralizing Antibody      
EER Adalimumab      

PRIMARY
1 Serum 1 (0.3) mL   Room Temperature - 48 Hour(s)/Refrigerated - 30 Day(s)/Frozen - 12 Month(s)  
ALTERNATE

This test measures the capacity of adalimumab to neutralize TNF-activity. Additionally, adalimumab neutralizing antibodies (NAb) are titered (reporting the highest dilution of patient sera in which NAb activity is detected). This test is used to evaluate secondary response failures to adalimumab therapy. Secondary response failure is defined as loss of clinical response after initial improvement of clinical signs and symptoms. Therapeutic decision should rest on both the clinical response and the knowledge of the fate of the drug including the emergence of immunogenicity in individual patients. Circulating adalimumab levels have been shown to vary considerably between patients. These differences relate to route and frequency of administration and patient-related features such as age, gender, weight, drug metabolism, and concomitant medications such as methotrexate and other immunosuppressants.

Patient Preparation: Collect specimens before adalimumab treatment.
Specimen Preparation: Separate serum from cells ASAP or within 2 hours
of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.
(Min: 0.3 mL)
Setup Schedule
Monday, Wednesday, Thursday, Saturday

Reported (Analytical Time)
4 days

CPT Code
86352x2

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Contaminated, hemolyzed, icteric, or lipemic specimens Transport Temperature: Refrigerated Methodology: Cell Culture/Quantitative Chemiluminescent Immunoassay /Semi-Quantitative Chemiluminescent Immunoassay






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