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94336: OncoHeme Next-Generation Sequencing for Myeloid Neoplasms Print View
Specimen Type      
Indication for Test      
NGSHM Result      
Pathogenic Mutations Detected      
Interpretation      
Clinical Trials      
Variants of Unknown Signif.      
Additional Notes      
Method Summary      
Disclaimer      
OncoHeme Panel Gene list      
Reviewed By:      

PRIMARY
1 Whole Blood EDTA 3 (1) mL   Room Temperature - 14 Day(s)/Refrigerated - 14 Day(s)  
ALTERNATE
  Whole Blood Heparin 3 (1) mL   Refrigerated - 14 Day(s)/Room Temperature - 14 Day(s)  
  Bone Marrow ACD   Room Temperature - 14 Day(s)/Refrigerated - 14 Day(s)  
  Periph Blood EDTA   Room Temperature - 14 Day(s)/Refrigerated - 14 Day(s)  
  Bone Marrow Heparinized   Room Temperature - 14 Day(s)/Refrigerated - 14 Day(s)  
  DNA, extracted   Room Temperature - 14 Day(s)/Refrigerated - 14 Day(s)/Frozen - 14 Day(s)  
  Periph Blood ACD   Refrigerated - 14 Day(s)/Room Temperature - 14 Day(s)  
  Periph Blood Hep (Green)   Refrigerated - 14 Day(s)/Room Temperature - 14 Day(s)  
  Whole Blood ACD 3 (1) mL   Refrigerated - 14 Day(s)/Room Temperature - 14 Day(s)  
  BM Aspirate in EDTA   Refrigerated - 14 Day(s)/Room Temperature - 14 Day(s)  

Evaluation of hematologic neoplasms at the time of diagnosis, to assist in appropriate classification and prognosis. Determining the presence of new clinically important gene mutation changes at relapse.

Peripheral blood and bone marrow specimens must arrive within 14 days
of collection.

Necessary information:
The following information is required:
1. Clinical Diagnosis
2. Pertinent clinical history
3. Clinical or morphologic suspicion
4. Date of collection
5. Specimen source

Peripheral blood
Collection Instructions:
1. Invert several times to mix blood.
2. Send specimen in original tube.
3. Label specimen as blood.

Bone marrow aspirate
Collection instructions:
1. Invert several times to mix bone marrow.
2. Send specimen in original tube.
3. Label specimen as bone marrow.

Extracted DNA
Collection instructions:
Label specimen as extracted DNA and source of specimen
Setup Schedule
Tuesday, Friday

Reported (Analytical Time)
14 days

CPT Code
81450

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Gross hemolysis; Bone marrow biopsies, slides, paraffin shavings or frozen tissues and paraffin-embedded tissues; paraffin-embedded bone marrow aspirates; moderately to severely clotted; or lithium heparin anticoagulant

Transport Temperature:
Room temperature only: Peripheral blood and Bone marrow aspirate
Frozen: Extracted DNA

Methodology: Somatic Mutation Detection by Next-Generation Sequencing (NGS)

Specimen Requirements:
Preferred:
3 mL (1 mL minimum) Peripheral blood collected in an EDTA (lavender-top) or ACD (yellow-top) tube or 2 mL (1 mL minimum) Bone marrow aspirate collected in an EDTA (lavender-top) or ACD (yellow-top) tube

Acceptable:
3 mL (1 mL minimum) Peripheral blood collected in a Heparin (green-top)tube or 2 mL (1 mL minimum) Bone marrow aspirate collected in a Heparin (green-top) tube or Entire specimen Extracted DNA in 1.5- to 2-mL tube with indication of volume and concentration of the DNA. (minimum is 100 mcL at 20 ng/mcL concentration)






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