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94621: 18-hydroxycorticosterone Print View
18-Hydroxycorticosterone LC/MS/MS    ng/dL 

PRIMARY
1 Serum Red Top 0.5 (0.25) mL   Room Temperature - 7 Day(s)/Refrigerated - 7 Day(s)/Frozen - 28 Day(s)  
ALTERNATE

Primary aldosteronism should be suspected whenever a patient has the triad of hypertension, hypokalemia, and inappropriate renal potassium wasting. The biggest challenge is the differential diagnosis between the more common adrenal adenoma and bilateral hyperplasia. Because adrenal adenomas increase the circulating levels of 18-hydroxycorticosterone (18-OH B), serum levels of 18-OH B may be useful to differentiate them from bilateral adrenal hyperplasia. The cutoff point appears to be about 50 ng/dL of serum. Most values are around 100 ng/dL. The higher the level of this precursor, the greater the possibility that an adrenal adenoma is present. J Clin Endocrinol Metab. 97: 881-9, 2012.

Collect specimen in a non-additive red top tube. Spin down
immediately and pour off into a 13 x 75 mm plastic transport tube.
Setup Schedule
Sunday, Tuesday

Reported (Analytical Time)
4-9 days

CPT Code
82542

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Gross hemolysis; moderate hemolysis; grossly lipemic; grossly icteric; serum separator tube
Transport Temperature: Frozen
Methodology: Liquid Chromatography/Tandem Mass Spectrometry






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