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94628: Beta-amyloid 42/40 Ratio And Apoe Isoform Panel, Csf Print View
ABeta 42 LC-MS/MS    pg/mL 
ABeta 40 LC-MS/MS    pg/mL 
ABeta 42/40 Ratio LC-MS/MS     
ApoE Isoform LC-MS/MS     
Interpretation      
ApoE Total LC-MS/MS    ug/mL 
Relative Risk LC-MS/MS     

PRIMARY
1 CSF 1.6 (0.8) mL   Frozen - 31 Day(s)/Refrigerated - 5 Day(s)/Room Temperature - 72 Hour(s)  
ALTERNATE

This test for CSF Beta-Amyloid and CSF/Serum Apolipoprotein E by LC-MS/MS monitors both CSF beta-amyloid 40 (AB40) and 42 (AB42) endogenous peptides, rather than only AB42. Total ApoE and ApoE isoform analysis, in conjuction with the AB42/40 ratio, can aid in assessing disease. The quantitation of both AB peptides permits the normalization of beta amyloid levels circulating in cerebrospinal fluid in different patients by using a ratio of beta-amyloid 42 /beta-amyloid 40, resulting in an improved sensitivity for monitoring cognitive impairment that can progress to Alzheimer's disease.

Quest does not perform this test for individuals under the age of 18.
Pre-test and post-test counseling is strongly recommended.
Setup Schedule
Sunday

Reported (Analytical Time)
5-12 days

CPT Codes
82542x2,82172

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
**This test is not available for New York patient testing.**

Specimen Requirement: Preferred: 1.6 mL (0.8 mL minimum) CSF collected in Polypropylene Collection tube

Reject Criteria: Specimen collected in a glass, polystyrene, or polycarbonate tube.

Methodology: Liquid Chromatography/Tandem Mass Spectrometry

Transport Temperature: Frozen






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