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94685: Systemic Sclerosis (scleroderma) 12 Antibodies Panel 2 Print View
Scl-70     SI 
CENP-A     SI 
CENP-B     SI 
RP11     SI 
RP155     SI 
U1-snRNP RNP A     SI 
U1-snRNP RNP C     SI 
U1-snRNP RNP-70kd     SI 
Fibrillarin     SI 
Th/To     SI 
PM/Scl-100     SI 
PM/Scl-75     SI 

PRIMARY
1 Serum 0.5 (0.3) mL   Room Temperature - 7 Day(s)/Refrigerated - 14 Day(s)/Frozen - 21 Day(s)  
ALTERNATE

Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, and cutaneous and visceral fibrosis. Some antibodies are considered highly specific for SSc, including Scl-70 (anti-topoisomerase 1) antibody, anti-centromere (CENP) antibodies, and anti RNA polymerase III antibody and are classification criteria for disease defined by the American College of Rheumatology. Centromere antibodies are found in patients with a limited form of cutaneous systemic sclerosis, "CREST" syndrome, a complex of subcutaneous calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias. RNA polymerase III antibodies target RNAP III epitopes 11 and 155. Antibodies to three major components of U1-snRNP (snRNP RNP A, U1-snRNP RNP C, U1-snRNP RNP-70kd): U1- are associated with scleroderma and inflammatory myopathy overlap syndromes. Anti-Antifibrillarin (anti-U3RNP) antibodies are associated with diffuse cutaneous SSc, frequent visceral involvement, and especially renal and cardiac involvement. In African-American patients, anti-fibrillarin antibodies are associated with severe pulmonary disease, pulmonary hypertension, severe small bowel involvement, and a poor prognosis. Anti-Th/To antibodies primarily bind to two proteins of the mitochondrial RNA processing (MRP) and the ribonuclease P complexes, are present in 1-13% of SSc patients, and are rarely found in other diseases. Anti-Th/To antibodies are primarily associated with localized cutaneous scleroderma, and associated with pericarditis, interstitial lung disease and a high frequency of "intrinsic" pulmonary hypertension, and a poorer prognosis. Autoantibodies to PM/Scl, the human exosome complex, are found in polymyositis/scleroderma overlap syndromes. The majority of anti-PM/Scl reactivity is directed to one of two proteins: PM/Scl100 and/or PM-Scl75.
Setup Schedule
Tuesday, Thursday, Saturday

Reported (Analytical Time)
Next day

CPT Codes
86235x10,84182x2

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature
Methodology: Line Blot






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