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This is a sendout test. Please note that turnaround time is defined as the anticipated time from set up day to results release.
S52219NY: AccuType™CP, Clopidogrel CYP2C19 Genotype (1-5) [NY] Print View
Cytochrome P450 2C19      

PRIMARY
1 Whole Blood EDTA 4 (2) mL   Refrigerated - 30 Day(s)/Room Temperature - 8 Day(s)/Frozen - 49 Day(s)  
ALTERNATE
  Whole Blood Heparin 4 (2) mL   Room Temperature - 8 Day(s)/Refrigerated - 30 Day(s)/Frozen - 49 Day(s)  
  Whole Blood ACD Sol A 4 (2) mL   Refrigerated - 30 Day(s)/Frozen - 49 Day(s)/Room Temperature - 8 Day(s)  

DETAILED ASSAY INFORMATION The cytochrome P450 gene products are responsible for metabolizing a large number of widely prescribed drugs. Clopidogrel (Plavix(R)) is metabolized by cytochrome P450 2C19 (CYP2C19, S-mephenytoin 4-prime-hydroxylase) to its active form. Poor metabolizers (PM) will require increased dosage to obtain therapeutic levels, while ultra-extensive metoblizers (UM) will require a decreased dosage due to higher than normal rates of drug metabolism. CYP2C19 catalyzes the hydroxylation of a number of clinically important drugs, including omeprazole, proguanil, hexobarbital, imipramine and to a lesser extent, propranolol and diazepam. CYP2C19 loss-of- function alleles were shown to be associated with a higher rate of subsequent cardiovascular events among patients with an acute myocardial infarction and were receiving clopidogrel treatment (N Engl J Med. 2009;360:363-375).
Setup Schedule
Monday-Friday

Reported (Analytical Time)
3 days

CPT Code
81225+2C

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
METHODOLOGY: PCR/Single Nucleotide Primer Extension CPT CODES: 83891,83892X2,83900,83901X4,83909,83914X10,83912






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