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This is a sendout test. Please note that turnaround time is defined as the anticipated time from set up day to results release.
S52361: ABL T315I Mutation in CML, Cell Based [19783X] Print View
ABL T315I Mutation, Cell   Negative   

PRIMARY
1 Whole Blood EDTA 6 (4) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  

Mutations in the kinase domain of Bcr-abl are the leading cause of acquired imatinib resistance. Although mutations have been identified in more than 30 different amino acids, the highest degree of resistance was associated with single-point mutation T3151 of the abl gene in the Bcr-abl fusion transcript. Early detection of T3151 mutation of CML patient in therapy or pre-therapy could allow alternative treatment before resistance is detected cytogenetically or before disease progression becomes evident.

Preferred sample type is whole blood. Bone marrow is acceptable.
INSTRUCTION: Collect 6 mL of whole blood or 3 mL bone marrow in
lavender-top (EDTA) tube. Whole blood or 3 mL bone marrow is shipped
refrigerated. Do not freeze whole blood or bone marrow. After
collection of the sample, draw date and time, as well as sample type,
must be written on the tube and included as requested information.
Ship sample immediately due to short stability of 72 hours. If the
stability of the sample cannot be determined, delay in result or
cancellation of test may occur.
Setup Schedule
Monday

Reported (Analytical Time)
9-11 days

CPT Code
81401+AT

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Methodology: Polymerase Chain Reaction, Fragment Analysis






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