This test will be used to measure serum TPO level in patients with thrombocytopenia of unknown cause. ITP (Idiopathic Thrombocytopenia purpura) is a common cause of thrombocytopenia. The diagnosis is based on exclusion criteria. Serum TPO levels are normal or only slightly elevated in ITP so that if TPO level is markedly elevated the diagnosis of ITP is strongly in doubt. Markedly elevated TPO level may occur in individuals with genetic mutations of CD110. New Drugs, non peptide thrombopoietin receptor agonist (CD110) are becoming increasingly used in patients with thrombocytopenia of ITP. The cost of these new drugs is very high. That is why it is important to know levels of TPO. Patients with elevated TPO levels do not respond to treatment with thrombopoietin receptor agonist. Knowing levels of TPO may help in predicting efficacy of response to an extremely expensive stimulating drug used in a wide variety of hematologic disorders. May reduce the need for platelet transfusions with all known complications and reduced cost of blood products by hospital.
Cytokine levels may demonstrate diurnal variation. Recommend
cytokine levels be determined at the same time of day for improved
Reported (Analytical Time)
The CPT codes provided are based on AMA guidelines and are for informational purposes only.
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Please direct any questions regarding coding to the payer being billed.