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This is a sendout test. Please note that turnaround time is defined as the anticipated time from set up day to results release.
S52521: Epidermal Growth Factor Receptor (EGFR) Mut. Analysis [16460] Print View
EGFR Mutation Analysis   Not detected   

PRIMARY
1 Tissue Paraffin Block 1 (1) g   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
ALTERNATE

EGFR kinase domain mutations are found in 10-15% of lung adenocarcinomas, particularly those occurring in younger patients without a smoking history, and identify tumors that may have significant clinical response to EGFR-targeted kinase inhibitors. PCR-based DNA sequencing is used to assess for mutations in exons 18-21 of EGFR, which are the sites of greater than 95% of somatic mutations observed in tumors. This assay will also detect the T790M mutation, which is commonly seen in acquired resistance. With this information, physicians will be able to select those patients who are most likely to respond to targeted lung cancer therapy. In addition, follow-up samples from patients with resistant or recurrent disease may demonstrate an acquired T790M mutation, where newer FDA-approved agents have been shown to be effective.

FFPE tissue block: Regular procedure for paraffin embedded tissue
block preparation.

Slide preparation: Cut one 3-5 um tissue section for H&E stain. Cut
3-5 10 um sections on non-charged regular glass slides for
microdissection. The slide should not be baked or melted. A new
blade must be used for each paraffin block, for cutting to prevent
cross contamination.

Minimum volume: 3x10 um sections; 1x4 um section with H&E stain
Standard volume: 5x10 um sections; 1x4 um section with H&E stain
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days

CPT Code
81235

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Methodology: (PCR) Polymerase Chain Reaction and Sequencing CPT CODES: 83891,83892,83912,83898X4,83904X4,83909X4






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